Dr. Shayan Sharif earned his Doctor of Veterinary Medicine degree from the Faculty of Veterinary Medicine, University of Tehran. Dr. Sharif became interested in immunogenetics (especially poultry immunogenetics) while preparing his DVM thesis, which was entitled "Immunological aspects of Marek's disease in chickens". Following his graduation, Dr. Sharif practised for close to two years as a veterinarian in the broiler industry in Iran. Subsequently, he came to Guelph to pursue a PhD degree in the area of Immunology and Immunogenetics in the Department of Veterinary Microbiology and Immunology, Ontario Veterinary College, University of Guelph. Dr. Sharif received a post-doctoral fellowship to begin his post-doctoral research in Immunology at The John Robrats Institute, London, Ontario. Dr. Sharif was recruited, as a member of the PIC-funded Poultry Program Team, to the Department of Pathobiology, University of Guelph to establish a research program in poultry immunology. Dr. Sharif's research is focused on elucidating the ways in which microbes interact with the chicken immune system. There are three main areas of research emphasis in Dr. Sharif’s lab: 1- Immunity and vaccines to Marek’s disease, 2- Immunity to avian influenza virus and vaccine development, 3- development of probiotics for enhanced immune responsiveness and gut health in poultry. The ultimate goal is to develop better strategies to maintain and promote poultry health.
Dr. Sharif has mentored over fifty graduate and undergraduate students, post-docs, research assistants, and undergraduate students.
Dr. Sharif currently serves as an Associate Editor for Avian Pathology and BMC Genomics. In addition, he is a member of the Editorial Board of Poultry Science and Veterinary Immunology and Immunopathology. Publications
- Replication of an H9N2 Avian Influenza Virus and Cytokine Gene Expression in Chickens Ex-posed by Aerosol or Intranasal Routes.
- Cytokine Gene Expression in Lung Mononuclear Cells of Chickens Vaccinated with Herpesvirus of Turkeys and Infected with Marek’s Disease Virus
- Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens
- Systemic immune responses to an inactivated, whole H9N2 avian influenza virus vaccine using class B CpG oligonucleotides in chickens
- Evaluation of a polysaccharide conjugate vaccine to reduce colonization by Campylobacter jejuni in broiler chickens
- Induction of antiviral responses against avian influenza virus in embryonated chicken eggs with toll-like receptor ligands
- Characterization of the effects of three Lactobacillus species on the function of chicken macrophages
- Effects of interferon-γ knockdown on vaccine-induced immunity against Marek’s disease in chickens
- Expression profiles of antiviral response genes in chicken bursal cells stimulated with Toll-like receptor ligands
- TLR ligands induce antiviral responses in chicken macrophages.
- Effects of ligands for Toll-like receptors 3, 4, and 21 as adjuvants on the immunogenicity of an avian influenza vaccine in chickens.
- Avian influenza virus vaccines containing Toll-like receptors 2 and 5 ligand adjuvants promote protective immune responses in chickens.
- The effects of administration of ligands for Toll-like receptor 4 and 21 against Marek’s disease in chickens.
- PHRN researchers in 2015 Agri-Food Yearbook
- TLR ligands induce antiviral responses in chicken macrophages
- Immunostimulatory properties of Toll-like receptor ligands in chickens.
- Cytokine patterns associated with a serotype 8 fowl adenovirus infection.
- Small Interfering RNA-Mediated Knockdown of Chicken Interferon-γ Expression.
- Induction of chicken cytokine responses in vivo and in vitro by lipooligosaccharide of Campylobacter jejuni HS:10.
- Treatment with ligands for toll-like receptors 2 and 5 induces a mixed T-helper 1- and 2-like response in chicken splenocytes.
- Characterization of chicken thrombocyte responses to Toll-like receptor ligands
- Toll-like receptor 3 ligand enhances protective effects of vaccination against Marek’s disease virus and hinders tumor development in chickens.
- Vaccination with CpG-adjuvanted avian influenza virosomes promotes antiviral immune responses and reduces virus shedding in chickens.
- Prophylactic treatment with Toll-like receptor ligands enhances host immunity to avian influenza virus in chickens.
- Influence of vaccination with CVI988/Rispens on load and replication of a very virulent Marek’s disease virus strain in feathers of chickens.
- Oral immunization of broiler chickens against necrotic enteritis with an attenuated Salmonella vaccine vector expressing Clostridium perfringens antigens.