Dr. Moussa Diarra's laboratory previously described Salmonella enterica serovar Heidelberg isolates harboring a chromosomal gene cluster similar to the glutathione S-transferase gene, a putative fosA gene conferring resistance to fosfomycin. Here, we show that this new gene, named fosA7, confers resistance to fosfomycin. The introduction of fosA7 into the fosfomycin-susceptible Salmonella enterica serovar Enteritidis resulted in a substantial increase in the fosfomycin MIC. This finding increases the awareness of antibiotic resistance in Salmonella Heidelberg from broilers as related to the food safety and public health.
Dr. Diarra is a Principal Research Scientist in Microbiology-Immunology with Agriculture and Agri-Food Canada (AAFC) located at the Guelph Research Center. His research is focused on antibiotic resistance and alternatives to antibiotics as well as bacterial pathogenesis and the interactions between pathogens and their hosts. He is the leader of the poultry node of an AAFC’s national study on assessing antimicrobial agents use and emerging bio-contaminants in Canadian Agriculture and Agri-food systems.
Link to full paper in the American Society for Microbiology - First Detection of a Fosfomycin Resistance Gene, fosA7 ,in Salmonella enterica Serovar Heidelberg Isolated from Broiler Chickens
American Society for Microbiology article - Canadian Team Finds New Antibiotic Resistance Gene in Salmonella from Broiler Chickens
News-2Center for Infectious Diesease Research and Policy - New resistance gene found in Salmonella isolated from chickens