Areas of Interest
- Immune response to Mareks disease virus in chickens
- Immunology of avian influenza virus infection in chickens
- Interactions between commensal bacteria in the intestine and the chicken immune system
The primary focus of Dr. Sharif's research group is to understand how the chicken immune system recognizes and responds to viral pathogens. His research group's focus is to elucidate the mechanisms involved in initiation and regulation of T cell response. To achieve this objective, they are utilizing new technology, including microarrays, mass spectrometry, tetramers, and real-time PCR to dissect the molecular mechanisms of immunity to viral pathogens.
Another area of research in Dr. Sharif's laboratory investigates the effects of intestinal microbiota manipulations, via antibiotics and probiotics, on control of enteric pathogens and development of immune system.
- Replication of an H9N2 Avian Influenza Virus and Cytokine Gene Expression in Chickens Ex-posed by Aerosol or Intranasal Routes.
- Cytokine Gene Expression in Lung Mononuclear Cells of Chickens Vaccinated with Herpesvirus of Turkeys and Infected with Marek’s Disease Virus
- Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens
- Systemic immune responses to an inactivated, whole H9N2 avian influenza virus vaccine using class B CpG oligonucleotides in chickens
- Evaluation of a polysaccharide conjugate vaccine to reduce colonization by Campylobacter jejuni in broiler chickens
- Induction of antiviral responses against avian influenza virus in embryonated chicken eggs with toll-like receptor ligands
- Characterization of the effects of three Lactobacillus species on the function of chicken macrophages
- Effects of interferon-γ knockdown on vaccine-induced immunity against Marek’s disease in chickens
- Expression profiles of antiviral response genes in chicken bursal cells stimulated with Toll-like receptor ligands
- TLR ligands induce antiviral responses in chicken macrophages.
- Effects of ligands for Toll-like receptors 3, 4, and 21 as adjuvants on the immunogenicity of an avian influenza vaccine in chickens.
- Avian influenza virus vaccines containing Toll-like receptors 2 and 5 ligand adjuvants promote protective immune responses in chickens.
- The effects of administration of ligands for Toll-like receptor 4 and 21 against Marek’s disease in chickens.
- PHRN researchers in 2015 Agri-Food Yearbook
- TLR ligands induce antiviral responses in chicken macrophages
- Immunostimulatory properties of Toll-like receptor ligands in chickens.
- Cytokine patterns associated with a serotype 8 fowl adenovirus infection.
- Small Interfering RNA-Mediated Knockdown of Chicken Interferon-γ Expression.
- Induction of chicken cytokine responses in vivo and in vitro by lipooligosaccharide of Campylobacter jejuni HS:10.
- Treatment with ligands for toll-like receptors 2 and 5 induces a mixed T-helper 1- and 2-like response in chicken splenocytes.
- Characterization of chicken thrombocyte responses to Toll-like receptor ligands
- Toll-like receptor 3 ligand enhances protective effects of vaccination against Marek’s disease virus and hinders tumor development in chickens.
- Vaccination with CpG-adjuvanted avian influenza virosomes promotes antiviral immune responses and reduces virus shedding in chickens.
- Prophylactic treatment with Toll-like receptor ligands enhances host immunity to avian influenza virus in chickens.
- Influence of vaccination with CVI988/Rispens on load and replication of a very virulent Marek’s disease virus strain in feathers of chickens.
- Oral immunization of broiler chickens against necrotic enteritis with an attenuated Salmonella vaccine vector expressing Clostridium perfringens antigens.