Dr. Moussa S. Diarra is a research scientist at Agriculture and Agri-Food Canada’s (AAFC) Guelph Research and Development Centre. His research is focused on antibiotic resistance and alternatives to antibiotics as well as bacterial pathogenesis and the interactions between pathogens and their hosts. He is the leader of the poultry node of an AAFC’s national […]
Treatment with ligands for toll-like receptors 2 and 5 induces a mixed T-helper 1- and 2-like response in chicken splenocytes.
St Paul M, Paolucci S and Sharif S. J Interferon Cytokine Res. 32:12 (2012):592-598. Abstract Toll-like receptors (TLRs) play an important role in the induction of host responses to pathogens. Interactions between TLRs and their ligands result in the production of cytokines that modulate the adaptive immune response through polarizing CD4+ T cells into either […]
Sequence of two plasmids from Clostridium perfringens chicken necrotic enteritis isolates and comparison with C. perfringens conjugative plasmids. 2012.
Parreira, V. R., Costa, M., Eikmeyer, F., Blom, J., Prescott, J. F. PLoS One 7: e49753. Abstract Twenty-six isolates of Clostridium perfringens of different MLST types from chickens with necrotic enteritis (NE) (15 netB-positive) or from healthy chickens (6 netB-positive, 5 netB-negative) were found to contain 1-4 large plasmids, with most netB-positive isolates containing 3 […]
Risk factors associated with the colonization of Ontario layer chicken flocks with Brachyspira species.
Medhanie GA1, McEwen SA, Weber L, Sanei B, Cooley L, Houghton S, Slavic D, Guerin MT. Abstract Brachyspira species are frequent colonizers of the gastrointestinal tract in a variety of domestic animals, including birds. In chickens, Brachyspira species are associated with a clinical condition known as avian intestinal spirochetosis (AIS), a disease characterized by chronic […]
Shojadoost, B., Vince, A. R., Prescott, J. F. Vet. Res. 43:74. Abstract Necrotic enteritis (NE) is one of the most important enteric diseases in poultry and is a high cost to the industry worldwide. It is caused by avian-specific, Necrotic Enteritis Beta toxin (NetB)-producing, strains of Clostridium perfringens that also possess in common other […]
St Paul M, Paolucci S, Barjesteh N, Wood RD, Schat KA and Sharif S. PLoS One. 7:8 (2012):e43381. Abstract Thrombocytes are the avian equivalent to mammalian platelets. In addition to their hemostatic effects, mammalian platelets rely in part on pattern recognition receptors, such as the Toll-like receptors (TLR), to detect the presence of pathogens […]
Toll-like receptor 3 ligand enhances protective effects of vaccination against Marek’s disease virus and hinders tumor development in chickens.
Parvizi P, Mallick AI, Haq K, Haghighi HR, Orouji S, Thanthrige-Don N, St Paul M, Brisbin JT, Read LR, Behboudi S and Sharif S. Abstract Marek’s disease (MD) is caused by Marek’s disease virus (MDV). Various vaccines including herpesvirus of turkeys (HVT) have been used to control this disease. However, HVT is not able […]
Boerlin P, Nicholson V, Brash M, Slavic D, Boyen F, Sanei B, Butaye P. Vet Microbiol. 2012 Jun 15;157(3-4):405-11. doi: 10.1016/j.vetmic.2012.01.001. Epub 2012 Jan 8. PubMed PMID: 22266160. Abstract Enterococcus cecorum is a normal inhabitant of the intestine of birds and other vertebrates. It has recently emerged in Canada and other countries as an important cause […]
Prophylactic treatment with Toll-like receptor ligands enhances host immunity to avian influenza virus in chickens.
Paul M, Mallick AI, Read LR, Villanueva AI, Parvizi P, Abdul-Careem MF, Nagy É and Sharif S. Vaccine. 30:30 (2012):4524-4531. Abstract Avian influenza viruses (AIV) pose a threat towards the health of both poultry and humans. To interrupt the transmission of the virus, novel prophylactic strategies must be considered which may reduce the shedding of […]
Bergeron CR, Prussing C, Boerlin P, Daignault D, Dutil L, Reid-Smith RJ, Zhanel GG, Manges AR. Canada. Emerg Infect Dis. 2012 Mar;18(3):415-21. doi: 10.3201/eid1803.111099. PubMed PMID: 22377351; PubMed Central PMCID: PMC3309577. Abstract We previously described how retail meat, particularly chicken, might be a reservoir for extraintestinal pathogenic Escherichia coli (ExPEC) causing urinary tract infections (UTIs) in humans. […]
Influence of vaccination with CVI988/Rispens on load and replication of a very virulent Marek’s disease virus strain in feathers of chickens.
Haq K, Fear T, Ibraheem A, Abdul-Careem MF and Sharif S. Avian Pathol. 41:1 (2012):69-75.
Identification of accessory genome regions in poultry Clostridium perfringens isolates carrying the NetB plasmid.
Lepp, D., Gong. J., Boerlin, P., Parreira, V. R., Songer, J. G., Prescott, J. F. 2012. Bact. 195:1152-1166. Abstract Necrotic enteritis (NE) is an economically important disease of poultry caused by certain Clostridium perfringens type A strains. NE pathogenesis involves the NetB toxin, which is encoded on a large conjugative plasmid within a 42-kb pathogenicity […]