Rapid generation of fowl adenovirus 9 vectors

J Virol Methods. 2015 Oct;223:75-81. doi: 10.1016/j.jviromet.2015.07.017. Epub 2015 Jul 31. Pei Y1, Griffin B1, de Jong J1, Krell PJ2, Nagy É3. Abstract Fowl adenoviruses (FAdV) have the largest genomes of any fully sequenced adenovirus genome, and are widely considered as excellent platforms for vaccine development and gene therapy. As such, there is a strong […]

Avian bornavirus in free-ranging waterfowl: prevalence of antibodies and cloacal shedding of viral RNA.

Delnatte P1, Nagy É, Ojkic D, Leishman D, Crawshaw G, Elias K, Smith DA. Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Abstract We surveyed free-ranging Canada Geese (Branta canadensis), Trumpeter Swans (Cygnus buccinator), Mute Swans (Cygnus olor), and Mallards (Anas platyrhynchos) to estimate the prevalence of antibodies to avian bornavirus (ABV) and […]

Comparison of fiber gene sequences of inclusion body hepatitis (IBH) and non-IBH strains of serotype 8 and 11 fowl adenoviruses.

Grgić H, Krell PJ, Nagy E ——————————————————————————————————- Fowl adenoviruses (FAdVs) are common in broiler operations, and the most frequently isolated FAdVs belong to serotypes 1, 8, and 11. Serotype 1 viruses are considered nonpathogenic. While some serotype 8 and 11 viruses cause inclusion body hepatitis (IBH), these virus serotypes can also be isolated from non-IBH […]

Cytokine patterns associated with a serotype 8 fowl adenovirus infection.

Grgić H, Sharif S, Haghighi HR and Nagy É. Viral Immunol. 2 (2013):143-149. Abstract This study examined cytokine gene expression patterns associated with fowl adenovirus (FAdV) infection. The selected cytokine mRNA was quantified by quantitative real-time reverse transcription-PCR in spleen, liver, and cecal tonsil during the course of infection of chickens with a serotype 8 FAdV (FAdV-8). Compared […]

Vaccination with CpG-adjuvanted avian influenza virosomes promotes antiviral immune responses and reduces virus shedding in chickens.

Mallick AI, Kulkarni RR, St Paul M, Parvizi P, Nagy E, Behboudi S and Sharif S.  Viral Immunol. 25:3 (2012):226-31. Abstract The use of virosomes as a vaccine platform has proven successful against several viruses. Here we examined the protective efficacy of a virosome-based vaccine consisting of avian influenza virus (AIV) A/Duck/Czech/56/H4N6 in chickens against […]